Oesophagostomum dentatum: Effect of glutathione S-transferase (GST) inhibitors on GST activity and larval development

► GST was purified from Oesophagostomum dentatum (porcine nodule worm). ► It was inhibited by sulphobromophthalein, indomethacin and ethacrynic acid. ► These substances also reversibly inhibit larval development in vitro. ► GST plays a vital role for nematode development, representing a potential drug target.