Ovarian cancer mortality and industrial pollution

- We studied excess mortality due to ovarian cancer near Spanish industries.
- Integrated nested Laplace approximations were used as a Bayesian inference tool.
- We found excess ovarian cancer mortality near all industrial groups as a whole.
- Risk also was found in towns near industries releasing carcinogens and metals.
- Risk was associated with plants releasing polycyclic aromatic chemicals and POPs.

We investigated whether there might be excess ovarian cancer mortality among women residing near Spanish industries, according to different categories of industrial groups and toxic substances. An ecologic study was designed to examine ovarian cancer mortality at a municipal level (period 1997-2006). Population exposure to pollution was estimated by means of distance from town to facility. Using Poisson regression models, we assessed the relative risk of dying from ovarian cancer in zones around installations, and analyzed the effect of industrial groups and pollutant substances. Excess ovarian cancer mortality was detected in the vicinity of all sectors combined, and, principally, near refineries, fertilizers plants, glass production, paper production, food/beverage sector, waste treatment plants, pharmaceutical industry and ceramic. Insofar as substances were concerned, statistically significant associations were observed for installations releasing metals and polycyclic aromatic chemicals. These results support that residing near industries could be a risk factor for ovarian cancer mortality.