Integrated use of antioxidant enzymes and oxidative damage in two fish species to assess pollution in man-made hydroelectric reservoirs

► Metals and organochlorines presented similar pathways of bioaccumulation. ► Organochlorines were associated to enzyme inhibition and LPO in June. ► Metal concentrations were associated to metallothionein in the liver. ► Contaminants were associated to catalase activity and LPO in December. ► Aldrin/Dieldrin was the contaminant more strongly associated to LPO.