Evaluating the effect of ambient particulate pollution on DNA methylation in Alaskan sled dogs: Potential applications for a sentinel model of human health

In this study we evaluated global methylation using LUMA and 5-mC and found no differences between kennels, though exposure to ambient PM2.5 was significantly different between kennels. As more information becomes available regarding immunologically-related canine genes and functionally active promoter subunits, the utility of this surrogate could increase.