کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6330176 | 1619781 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prenatal pyrethroid insecticide exposure and thyroid hormone levels and birth sizes of neonates
ترجمه فارسی عنوان
قرار گرفتن در معرض حشره کش های پریتروئید پیش از قاعدگی و میزان هورمون های تیروئید و اندازه نوزادان
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کلمات کلیدی
مادر جفت نوزاد اسید 3-فینوکسی بنزوئیک ادرار، تیروکسین آزاد، هورمون تحریک کننده تیروئید، وزن تولد، دور سر،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
چکیده انگلیسی
Pyrethroid insecticides have been shown to possess thyroid hormone disrupting properties in previous animal studies. In this study, the relationship between maternal exposure to pyrethroid insecticides during pregnancy and neonatal thyroid hormone status (free thyroxine (fT4) and thyroid stimulating hormone (TSH) in whole blood) and birth sizes were explored in 147 mother-neonate pairs in Tokyo. The concentration of 3-phenoxybenzoic acid (3-PBA) in maternal urine, sampled in the first trimester of gestation, was used for pyrethroid exposure assessment. Neonatal fT4 and TSH were within the normal range except for one elevated TSH (but normal fT4) in a neonate. Multiple regression analyses with stepwise variable selection did not extract maternal 3-PBA as significant for neonatal fT4 and TSH, indicating that maternal pyrethroid exposure had no apparent effect on the neonatal thyroid hormone status of the neonate subjects. For birth weight and head circumference, maternal 3-PBA was selected as significant with a positive partial regression coefficient along with other factors known to increase birth sizes of neonates (gestational weeks or maternal BMI). It was not clear if this was causal because no biological mechanism was apparent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volumes 488â489, 1 August 2014, Pages 275-279
Journal: Science of The Total Environment - Volumes 488â489, 1 August 2014, Pages 275-279
نویسندگان
Jie Zhang, Jun Yoshinaga, Aya Hisada, Hiroaki Shiraishi, Kazuhisa Shimodaira, Takashi Okai, Maiko Koyama, Noriko Watanabe, Emiko Suzuki, Miyako Shirakawa, Yumiko Noda, Yoko Komine, Nagako Ariki, Nobumasa Kato,