کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6331395 1619793 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ecotoxicological evaluation of caffeine and its derivatives from a simulated chlorination step
ترجمه فارسی عنوان
ارزیابی اکسی سیکلوسیک کافئین و مشتقات آن از یک مرحله کلر زنی شبیه سازی شده
کلمات کلیدی
کافئین، درمان ضد عفونی، کلر زنی، مشتقات کلر، سمیت حاد و مزمن، سمیت ژنتیکی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی
Caffeine is ubiquitous in surface and ground waters and it has been proposed as a marker of the anthropogenic pressure on the environment. Sewage treatment plants based on active sludges seem to be not very efficient in its complete removal from effluents while additional disinfection treatments by chlorination are able to do it. In a simulation of the chlorination step herein we report that caffeine is transformed in six by-products: 8-chlorocaffeine, 1,3-dimethyl-5-azabarbituric acid, N,N′-dimethylparabanic acid, N,N′-dimethyloxalamide, N-methylurea and N,N′-dimethylurea. The ecotoxicity of caffeine and identified compounds was evaluated on the rotifer Brachionus calyciflorus and the alga Pseudokirchneriella subcapitata to assess acute and chronic toxicity, while SOS Chromotest and Ames Test were used to detect the genotoxic potential of the investigated compounds. Moreover, we assessed the possible antigenotoxic effect of the selected compounds using SOS Chromotest after co-incubation with the standard genotoxin, 4-nitroquinoline 1-oxide. Chronic exposure to these compounds caused inhibition of growth population on the rotifer while the algae seemed to be unaffected. Results indicated that caffeine (1), N,N′-dimethyloxamide (4) and N,N′-dimethylparabanic acid (5) reduced β-galactosidase activity in comparison with positive control, both at 1 and 5 mg/L of 4-NQNO with a good dose-response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volumes 470–471, 1 February 2014, Pages 453-458
نویسندگان
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