کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6332577 1619794 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hexabromocyclododecane concentrations in Canadian human fetal liver and placental tissues
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Hexabromocyclododecane concentrations in Canadian human fetal liver and placental tissues
چکیده انگلیسی
Detectable concentrations of the flame retardant hexabromocyclododecane (HBCD) have been reported in human tissues worldwide, but investigations to determine fetal exposure to this brominated flame retardant are lacking. This study was undertaken to determine the concentrations of α-, β- and γ-HBCD in human tissues (fetal liver and placenta) from Canada. Tissue samples were collected over a thirteen year period following elective pregnancy terminations in Montreal, Quebec, Canada. Samples were extracted using homogenisation with solvent, cleaned up using adsorption chromatography and analysis was performed with liquid chromatography-tandem mass spectrometry. Total HBCD concentrations ranged from below the limit of detection (< LOD; < 1 ng g− 1) to 4500 ng g− 1 lipid in fetal livers and < LOD (< 1 ng g− 1) to 5600 ng g− 1 lipid in placental tissue. No clear temporal trend was established in liver samples, nor was a significant relationship observed between fetal age and ΣHBCD concentrations. Temporal differences, however, were noted in placental tissues before and after 2005. HBCD concentrations in liver:placental paired tissue samples did not show a correlation. HBCD was found in placental tissues from Canadian women and results indicate that HBCD was present, at measurable concentrations, in developing fetuses from as early as 6.5 weeks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volumes 468–469, 15 January 2014, Pages 622-629
نویسندگان
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