A new perspective on human health risk assessment: Development of a time dependent methodology and the effect of varying exposure durations

► A human health, Time Dependent Risk Assessment (TDRA) methodology is presented. ► TDRA relays information on the magnitude, duration, and fluxes of risk in time. ► Kinetic and equilibrium concentration signals show sensitivity in TDRA results. ► In the TDRA results, individual susceptibility affects how risk changes in time. ► Otherwise lost information on risk uncertainty is captured in this new method.