Comparison of thiol subproteome of the vent mussel Bathymodiolus azoricus from different Mid-Atlantic Ridge vent sites

► Thiol proteins play major roles in stress defence and are susceptible to oxidation. ► Activated thiol sepharose was used to isolate thiol proteins in vent mussels. ► Thiol proteins in mussels from high metal levels sites were significantly less abundant. ► Differently expressed proteins reflect adaptation mechanisms to extreme environments. ► Mussels have different susceptibilities to oxidative stress depending on the vent site.