کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6352383 | 1622559 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adulthood dietary exposure to a common pesticide leads to an obese-like phenotype and a diabetic profile in apoE3 mice
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کلمات کلیدی
DTNB, 5BChEALTHOMA-IR4-(2-aminoethyl) benzenesulfonyl fluoride hydrochlorideAEBSFCPFbutyrylcholinesteraseAST - آسپارتات ترانس آمینازPesticide - آفت کشalanine transaminase - آلانین ترانس آمینازACh - آهApoe - آپوapolipoprotein E - آپولیپوپروتئین EHomeostatic model assessment for insulin resistance - ارزیابی مدل هومستاتیک برای مقاومت به انسولینOrganophosphate - ارگانوفسفاتAcetylcholine - استیل کولینDiabetes - بیماری قندaspartate transaminase - ترانس آمیناز آسپارتاتWorld Health Organization - سازمان بهداشت جهانیLeptin - لپتین Obesity - مرض چاقیChlorpyrifos - کلرپیریفوسCHE - کهWHO - کهCholinesterase - کولین استرازGhrelin - گرلین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Increasing evidence links the widespread exposure to organophosphate (OP) pesticides to the global epidemics of type 2 diabetes and obesity. Our recent data highlighted geneÃenvironment interactions: mice expressing the human apolipoprotein E3 (apoE3) isoform were more prone to develop obesity than those expressing apoE2 or apoE4 upon dietary challenge with chlorpyrifos (CPF), the most used OP worldwide. Thus, we aimed to further explore the contribution of the APOE3 genotype on the emergence of obesity and related metabolic dysfunctions upon subchronic exposure to CPF. Seven-month-old targeted replacement apoE3 and C57BL/6N male mice were orally exposed to CPF at 0 or 2Â mg/kg body weight/day for 8 consecutive weeks. We examined body weight status, food and water intake, lipid and glucose homeostasis, metabolic biomarkers concentrations, insulin levels and insulin resistance, and leptin and ghrelin profiles. CPF exposure generally increased food ingestion, glucose and total cholesterol concentrations, and tended to elevate acyl ghrelin levels. Nonetheless, excess weight gain and increased leptin levels were inherent to apoE3 mice. Moreover, the propensity towards a diabetic profile was markedly higher in these animals than in C57BL/6N, as they showed a higher homeostatic model assessment for insulin resistance index and higher insulin levels. Although both genotypes were metabolically affected by CPF, the results of the present investigation revealed that apoE3 mice were the most vulnerable to developing obesity and related disturbances following CPF administration through the diet. Since the APOE3 genotype is the most prevalent worldwide, current findings have particular implications for human health.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 142, October 2015, Pages 169-176
Journal: Environmental Research - Volume 142, October 2015, Pages 169-176
نویسندگان
Fiona Peris-Sampedro, Maria Cabré, Pia Basaure, Ingrid Reverte, José L. Domingo, Maria Teresa Colomina,