کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6352971 | 1622569 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of urine concentration adjustment method on associations between urine metals and estimated glomerular filtration rates (eGFR) in adolescents
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کلمات کلیدی
IQCDRC-ICP-MSMDLEGFRHNO3C2CNISTOsmolality - اسمولالیته standard deviation. - انحراف معیار.Uranium - اورانیومbody mass index - شاخص توده بدنBMI - شاخص توده بدنیCoefficient of Variation - ضریب تغییرUrine concentration - غلظت ادرارMethod Detection Limit - محدودیت تشخیص روشNational Institute of Standards and Technology - موسسه ی ملی استانداردها و تکنولوژیestimated glomerular filtration rate - میزان تصفیه گلومرولی برآورد شده استNitric acid - نیتریک اسید، اسید نیتریک Cadmium - کادمیمcreatinine - کراتینینinternal quality control - کنترل کیفیت داخلی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Positive associations between urine toxicant levels and measures of glomerular filtration rate (GFR) have been reported recently in a range of populations. The explanation for these associations, in a direction opposite that of traditional nephrotoxicity, is uncertain. Variation in associations by urine concentration adjustment approach has also been observed. Associations of urine cadmium, thallium and uranium in models of serum creatinine- and cystatin-C-based estimated GFR (eGFR) were examined using multiple linear regression in a cross-sectional study of adolescents residing near a lead smelter complex. Urine concentration adjustment approaches compared included urine creatinine, urine osmolality and no adjustment. Median age, blood lead and urine cadmium, thallium and uranium were 13.9 years, 4.0 μg/dL, 0.22, 0.27 and 0.04 g/g creatinine, respectively, in 512 adolescents. Urine cadmium and thallium were positively associated with serum creatinine-based eGFR only when urine creatinine was used to adjust for urine concentration (β coefficient=3.1 mL/min/1.73 m2; 95% confidence interval=1.4, 4.8 per each doubling of urine cadmium). Weaker positive associations, also only with urine creatinine adjustment, were observed between these metals and serum cystatin-C-based eGFR and between urine uranium and serum creatinine-based eGFR. Additional research using non-creatinine-based methods of adjustment for urine concentration is necessary.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 132, July 2014, Pages 226-232
Journal: Environmental Research - Volume 132, July 2014, Pages 226-232
نویسندگان
Virginia M. Weaver, Gonzalo GarcÃa Vargas, Ellen K. Silbergeld, Stephen J. Rothenberg, Jeffrey J. Fadrowski, Marisela Rubio-Andrade, Patrick J. Parsons, Amy J. Steuerwald, Ana Navas-Acien, Eliseo Guallar,