کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
636483 | 1456124 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Electrospun PLGA/collagen nanofibrous membrane as early-stage wound dressing
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
تصفیه و جداسازی
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چکیده انگلیسی
Electrospinning of polylactide-polyglycolide (PLGA)/collagen in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) to fabricate a biomimetic nanofibrous extracellular membranes for wound dressing and tissue engineering was investigated. The morphology of as-spun PLGA/collagen nanofibers was examined by scanning electron microscopy. The average diameter of electrospun nanofibers was 250Â nm (range of 150-650Â nm). Degradation rate of PLGA/collagen nanofibrous membranes, cytocompatibility and cellular responses to membranes, cell and nanofibers interactions, and open wound healing in rats were studied. It was found that nanofibrous membranes made of PLGA/collagen were functionally active in responses in human fibroblasts, and were very effective as wound-healing accelerators in early-stage wound healing. The empirical results in this study indicate that electrospun PLGA/collagen nanofibers may be a good candidate as a wound dressing for skin regeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Membrane Science - Volume 355, Issues 1â2, 15 June 2010, Pages 53-59
Journal: Journal of Membrane Science - Volume 355, Issues 1â2, 15 June 2010, Pages 53-59
نویسندگان
Shih-Jung Liu, Yi-Chuan Kau, Chi-Yin Chou, Jan-Kan Chen, Ren-Chin Wu, Wen-Ling Yeh,