کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6369959 | 1623841 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparative genomics study of Salmonella Typhimurium LT2 for the identification of putative therapeutic candidates
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
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![عکس صفحه اول مقاله: Comparative genomics study of Salmonella Typhimurium LT2 for the identification of putative therapeutic candidates Comparative genomics study of Salmonella Typhimurium LT2 for the identification of putative therapeutic candidates](/preview/png/6369959.png)
چکیده انگلیسی
A computational, comparative genomics workflow was defined for the identification of novel therapeutic candidates against Salmonella Typhimurium LT2, with the aim that the selected targets should be essential to the pathogen, and have no homology with the human host. Bioinformatics analysis identified 43 proteins as non-host essential, which could serve as potential drug and vaccine targets. Additional prioritization parameters characterized 13 proteins as vaccine candidates while druggability of each of the identified proteins was evaluated by the Drug Bank database prioritized same number proteins suitable for drug targets. As a case study we built a homology model of one of the potential drug targets MurD ligase using MODELLER (9v12) software. The model has been further explored for in silico docking study with the inhibitors having druggability potential from the Drug Bank database. Results from this study could facilitate selective S. Typhimurium LT2 proteins for drug design and vaccine production pipelines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 369, 21 March 2015, Pages 67-79
Journal: Journal of Theoretical Biology - Volume 369, 21 March 2015, Pages 67-79
نویسندگان
Himanshu Bhusan Samal, Jyoti Prava, Mrutyunjay Suar, Rajani Kanta Mahapatra,