Isoquinoline alkaloid fractions of Fumaria officinalis: Characterization and evaluation of their antioxidant and antibacterial activities

Antibacterial activity was evaluated using liquid medium against Acinetobacter calcoaceticus, Propionibacterium acnes and Corynebacterium xerosis. Evaluation of minimum inhibitory concentration (MIC) showed low values, indicating an interesting antibacterial capacity. The MIC of 0.33 mg/mL recorded against Propionibacterium acnes with alkaloid extracts showed the effectiveness of this plant as an antibacterial agent. The greater effectiveness of the acid fraction (AF) and the total alkaloid extract (TA) against the three strains tested was correlated to their richness in protopine with levels of 51.75% and 34.48%, respectively.