کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
639533 1456193 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A parametric study of iontophoretic transdermal drug-delivery systems
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تصفیه و جداسازی
پیش نمایش صفحه اول مقاله
A parametric study of iontophoretic transdermal drug-delivery systems
چکیده انگلیسی
A mathematical model of iontophoretic transdermal drug delivery was applied to study the effects of physical parameters on the cumulative amount of amitriptyline HCl collected. A graphical method, based on an analytical solution of the system, was first used to estimate the drug diffusion coefficient in the membrane and its surface concentration in the absence of an electric potential difference. These initial values were improved by using an orthogonal collocation-based non-linear regression routine written in Mathematica (Wolfram Research Inc.). Assuming that the diffusion coefficient did not change, the surface concentration of the drug, following transdermal iontophoresis, was evaluated by a similar technique. Two case studies are presented. The first one, taken from the literature, verifies the validity of the procedure. The second case study is based on laboratory experiments using transport amitriptyline HCl across cadaver skin. Excellent agreement was observed between experimental and predicted values. The results support previous findings that the increase in the iontophoretic transdermal delivery of some drugs is mainly due to a rise in the surface concentration of the drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Membrane Science - Volume 278, Issues 1–2, 5 July 2006, Pages 124-132
نویسندگان
, , , ,