کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6423 490 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Computer simulation of cell entry of graphene nanosheet
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Computer simulation of cell entry of graphene nanosheet
چکیده انگلیسی

Recent studies suggest the great promise of functionalized nanosized graphene in biomedical applications, but the transmembrane translocation mechanisms of this two-dimensional nanomaterial have remained poorly understood. Understanding how graphene interacts with cell membrane is related to the fundamental biological responses and cytotoxicity, and is thereby one critical issue to be resolved before further applications of graphene in nanomedicine. Here, by using computer simulations, we explore the translocation of graphene nanosheet (GN) across lipid bilayer membrane and the roles of size and edge of GN in the process. We discover the permeation of small GN into bilayer center through insertion and rotation driven by transbilayer lateral pressure. For large GNs, the translocation undergoes a vesiculation process driven by complicated energetic contributions. Circular GNs with smooth edge show faster translocation but similar mechanisms with square GNs. Our results are fundamentally essential for optimized design of GNs towards extensively biological and biomedical applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 34, Issue 17, June 2013, Pages 4296–4301
نویسندگان
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