Catalysis without a headache: Modification of ibuprofen for the design of artificial metalloenzyme for sulfide oxidation

• An original artificial monooxygenase is designed based on iron embedding in serum albumin.
• easy to use catalytic sulfoxidation of thioanisole is performed.
• high stability of this hybrid is demonstrated.

A new artificial oxidase has been developed for selective transformation of thioanisole. The catalytic activity of an iron inorganic complex, FeLibu, embedded in a transport protein NikA has been investigated in aqueous media. High efficiency (up to 1367 t), frequency 459 TON min−1 and selectivity (up to 69%) make this easy to use catalytic system an asset for a sustainable chemistry.

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