A fast adaptive power scheme based on temperature distribution and convergence value for optimal hyperthermia treatment

To elevate tissue temperature to therapeutic level fast with optimal power deposition during hyperthermia treatment (HT) is a key treatment processing step. Traditionally we have treated the tumor volume, without considering possible existing thermally significant vessels, using a simple 1st-order temperature-based adaptive power scheme to determine optimal power deposition distributions. The objectives of this study were to reveal the difficulty of that approach when considering single large blood vessel, and proposed a novel fast scheme that could improve upon and substitute for the traditional temperature-based adaptive power scheme. In this study, we presented a novel three-coefficient-and-two-SCV 5th-order temperature-based adaptive power scheme to resolve the induced large blood vessel problem in 3-D temperature distribution and introduced the parameter, SCV (Sentinel Convergence Value), to handle interior scheme shift. Results of the novel adaptive power scheme has shown its robustness to fast approach optimal temperature distribution and power density distribution with high precision in the tumor volume when considering the existence of thermally significant blood vessel. Ultimately, we may be able to effectively calculate the absorbed power density distribution of 3-D biological tissues with a complicated vasculature [1] in the volume.

► A novel three-coefficient-and-two-SCV 5th –order temperature-based adaptive power scheme has been proposed and investigated for hyperthermia treatments with large blood vessels in tumors.
► The optimization process has been drastically shortened with this novel adaptive power scheme to obtain optimal power and temperature distributions for the tumor treatments.
► This novel adaptive power scheme can effectively adjust the power deposition in the tumor tissue adjacent to the large blood vessels.