Solubility measurement and correlation of the form A of ibrutinib in organic solvents from 278.15 to 323.15 K

• The solubility of ibrutinib (form A) in organic solvents was firstly reported.
• Apelblat, λh, empirical polynomial equations were used to correlate the solubility.
• The solubility order: MEK > acetone > EA > 1-butanol > acetonitrile ≈ IPA > MTBE.

In this work, the solubility of the form A of ibrutinib in isopropanol (IPA), 1-butanol, ethyl acetate (EA), acetonitrile, acetone, methyl ethyl ketone (MEK) and methyl tertiary butyl ether (MTBE) was firstly experimentally determined by a gravimetric method in the temperature range from 278.15 to 323.15 K at atmospheric pressure. The experimental solubility data were correlated by several commonly used models including the modified Apelblat equation, the Buchowski-Ksiazczak λh equation and an empirical quartic polynomial equation. The results showed that, in the temperature range investigated, the solubility of ibrutinib generally increased with the increasing temperature, and the solubility order at the room temperature in the studied solvents was: MEK > acetone > ethyl acetate > 1-butanol > acetonitrile ≈ isopropanol > MTBE. In addition, all the models gave satisfactory correlation results, in which the empirical quartic polynomial equation stood out to be more suitable with a higher accuracy than the other two equations.

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