کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6481380 1398100 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced bacteria adhesion on octenidine loaded mesoporous silica nanoparticles coating on titanium substrates
ترجمه فارسی عنوان
کاهش چسبندگی باکتریها در پوشش نانوذرات سیلیکا مشتق شده از اکتینیدین بر روی بسترهای تیتانیوم
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی


- MSNs incorporated titania coating is deposited onto Ti substrates via EEMAO.
- The coating is utilized for loading antibacterial agent of OCT.
- The coating improves the corrosion resistance of Ti substrates.
- The coated Ti substrates effectively reduce the adhesion of S. aureus and E. coli.
- The coated Ti substrates display good cytocompatibility for osteoblasts.

Bacterial infection is one of the most severe postoperative complications leading to implantation failure. The early bacterial stage (4-6 h) was proved to be the “decisive period” for long-term bacteria-related infection. Thus, to endow potential early antibacterial capacity for a titanium (Ti) based implant, an effective antiseptic agent of octenidine dihydrochloride (OCT) was effectively loaded on the mesoporous silica nanoparticles (MSNs)-incorporated titania coating which was fabricated by an electrophoretic-enhanced micro-arc oxidation technique. The surface characteristic of the coatings were characterized by various methods (SEM, AFM, XPS, XRD, etc.), and its corrosion resistance was also examined by the potentiodynamic polarization curves. The composite coating without OCT loading not only displayed good cytocompatibility but also exhibited certain anti-bacterial property. After loading with OCT, its antibacterial efficiency of the titanium substrates with composite coating was greatly enhanced without compromising their cytocompatibility. The study provides an approach for the fabrication of anti-bacterial Ti implant for potential orthopedic application.

Graphic abstract167

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 70, Part 1, 1 January 2017, Pages 386-395
نویسندگان
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