کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6481650 1400352 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes
چکیده انگلیسی


- IAV infection activates transcription of antiviral genes.
- NS1 protein of IAV binds cellular DNA.
- NS1-dsDNA interaction prevents loading of transcriptional machinery.
- Thus, NS1 suppresses IAV-mediated transcription of antiviral genes.

Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1859, Issue 11, November 2016, Pages 1440-1448
نویسندگان
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