کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6481699 1540227 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Resveratrol cross-linked chitosan loaded with phospholipid for controlled release and antioxidant activity
ترجمه فارسی عنوان
کیتوسان کریستال ریوی روراسترول حاوی فسفولیپید برای آزادی کنترل و فعالیت آنتی اکسیدانی است
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


- RVC-lipid nanoparticles were prepared by simple double emulsion technique.
- Phospholipids membrane demonstrates good encapsulation efficiency of 85.59%.
- Encapsulation decreases the antioxidant activity of resveratrol.
- Phospholipids encapsulation offers innovative platform for developing efficient delivery systems of nutraceutical.

Despite the therapeutic effects of resveratrol, its clinical application is restricted by its poor oral bioavailability and low water solubility. To overcome these physicochemical and pharmacokinetic limitations, encapsulation of resveratrol (RV) into nanodevices has been explored. Resveratrol cross-linked chitosan nanoparticles modified with phospholipids (RVC-lipid) were synthesized using a double emulsion technique. The surface morphology of RVC-lipid nanoparticles was evaluated with field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). Particle size was measured using dynamic light scattering technique (DLS), X-ray diffraction (XRD) was performed to identify the crystallographic nature and Fourier transform infrared spectroscopy (FTIR) was used to measure changes in the chemical structures of the resveratrol and RVC-lipid nanoparticles. Results showed RVC-lipid nanoparticle had a characteristic amorphous structure, a mean particle sizes of 570 nm in DI water and 950 nm in ethanol, and an encapsulation efficiency of 63.82% in aqueous medium and 85.59% in ethanol medium. In-vitro release studies demonstrated a slow and sustained release of resveratrol governed by diffusion. Based on assays of antioxidant activity the scavenging activity of RVC-lipid nanoparticles was inferior to that of resveratrol due to its prolonged release. We concluded that phospholipids are the potential carriers for resveratrol.

169

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 93, Part A, December 2016, Pages 757-766
نویسندگان
, , , , , , ,