کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6486539 | 1416254 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Beyond malaria: The inhibition of viruses by artemisinin-type compounds
ترجمه فارسی عنوان
فراتر از مالاریا: مهار ویروس ها با ترکیبات آرتمیسینین
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
polyomavirus BKArtemisia annuaJCPyVHCMVBVDVHHVIC50HSV-1EBTR50% inhibitory dose - 50٪ دوز مهاریROS - ROSSesquiterpene - اسکای مرطوبEBV - اپشتین بار ویروسAIDS - ایدزBKV - حمل و نقل عمومیAntiviral therapy - درمان ضد ویروسیacquired immunodeficiency syndrome - سندرم نقص ایمنی به دست آوردHuman cytomegalovirus - سیتومگالوویروس انسانیPhytochemicals - فیتوکمیکال هاHBV - هپاتیت بHCV - هپاتیت سیHepatitis C virus - هپاتیت سیEpstein-Barr virus - ویروس Epstein-Barrbovine viral diarrhea virus - ویروس اسهال ویروسی گاوHuman herpesvirus - ویروس انسانی انسانیhuman immunodeficiency virus - ویروس نقص ایمنی انسانیHIV - ویروس نقص ایمنی انسانی hepatitis B virus - ویروس هپاتیت بیHuman papillomavirus - ویروس پاپیلوم انسانیHPV - ویروس پایپلوم انسانیReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Natural products represent valuable chemical scaffolds for drug development. A recent success story in this context was artemisinin, which is not only active against malaria but also to other diseases. This raised the interest of artemisinin's potential for drug repurposing. On the present review, we give an overview on artemisinin's antiviral activity. There is good in vitro and in vivo evidence for the activity of artemisinin and its derivatives against DNA viruses of the Herpesviridae and Hepadnaviridae families such as cytomegaloviruses, human herpesvirus 6, herpes simplex viruses 1 and 2, Epstein-Barr virus and Hepatitis B virus. The evidence is weaker for Polyomaviruses and papilloma viruses. Weaker or no inhibitory activity in vitro has been reported for RNA viruses such as human immunodeficiency viruses 1 and 2, hepatitis C virus, influenza virus and others. Interestingly, the artemisinin derivative artesunate did not exert cross-resistance to ganciclovir-resistant HCMV and exerted synergistic inhibition in combination with several clinically established antiviral standard drugs. The antiviral activity of first generation artemisinin derivatives (e.g. artesunate, artemether, etc.) was enhanced by novel derivatives, including dimer and trimer molecules. First results on patients indicating activity in a subset of HCMV patients. Novel developments in the field of nanotechnology and synthetic biology to bioengineer microorganisms for artemisinin production may pave the way for novel drugs to fight viral infections with artemisinin-based drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biotechnology Advances - Volume 36, Issue 6, 1 November 2018, Pages 1730-1737
Journal: Biotechnology Advances - Volume 36, Issue 6, 1 November 2018, Pages 1730-1737
نویسندگان
Thomas Efferth,