Graphite oxide as catalyst for diastereoselective Mukaiyama aldol reaction of 2-(trimethylsilyloxy)furan in solvent free conditions

• Diastereoselective Mukaiyama aldol reaction was promoted by graphite oxide.
• Good diastereoselective control was exerted by graphite oxide catalyst.
• The reaction can be catalyzed by graphite oxide in solvent free conditions.
• The catalyst can be easily recovered making the procedure cheap and sustainable.

Abstract Graphite oxide efficiently promotes the stereoselective Mukaiyama aldol reaction of 2-(trimethylsilyloxy) furan in solvent free conditions assuring a good level of diastereoselectivity. The catalyst can be easily recovered and reused making the procedure cheap and sustainable. The GO ability to control the stereochemical pathway opens new scenes for the possible application in other synthetic transformations.

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