کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6494326 | 44805 | 2015 | 49 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metabolic engineering of Escherichia coli for the production of phenylpyruvate derivatives
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
3-deoxy-d-arabino-heptulosonate-7-phosphateDAHP synthaseE4PDAHPPPDPALPPPPEPPTSEPSP - epspiErythrose 4-phosphate - اریتروسی 4-فسفاتTAL - ازStyrene - استایرنEscherichia coli - اشریشیا کُلیSynthetic biology - سنتتیک بیولوژیphosphoenolpyruvate - فسفوآنولپیرواتPhenylglycine - فنیل گلیسینPhenylpropanoids - فینیل پروپانوئید هاPhenylpyruvate - فینیل پریوواتpentose phosphate pathway - مسیر پنتوز فسفاتTCA cycle - چرخه TCAtricarboxylic acid cycle - چرخه اسید تریکاربوکیلیک
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Phenylpyruvate derivatives (PPD), such as phenylpropanoids, dl-phenylglycine, dl-phenylalanine, and styrene, are biosynthesized using phenylpyruvate as the precursor. They are widely used in human health and nutrition products. Recently, metabolic engineering provides effective strategies to develop PPD producers. Based on phenylpyruvate-producing chassis, genetically defined PPD producers have been successfully constructed. In this work, the most recent information on genetics and on the molecular mechanisms regulating phenylpyruvate synthesis pathways in Escherichia coli are summarized, and the engineering strategies to construct the PPD producers are also discussed. The enzymes and pathways are proposed for PPD-producer constructions, and potential difficulties in strain construction are also identified and discussed. With respect to recent advances in synthetic biology, future strategies to construct efficiently producers are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolic Engineering - Volume 32, November 2015, Pages 55-65
Journal: Metabolic Engineering - Volume 32, November 2015, Pages 55-65
نویسندگان
Shuang Ping Liu, Liang Zhang, Jian Mao, Zhong Yang Ding, Gui Yang Shi,