Evaluation of SILP-Pd catalysts for Heck reactions in a microfluidics-based high throughput flow reactor

• Palladium catalysts immobilised on a supported ionic liquid phase were prepared.
• Catalysts were tested in Heck reaction in batch and continuous mode reactors.
• Two catalysts showed stable performance for several hours on stream.
• A catalyst with good stability and excellent selectivity was developed.

Heck reaction of aryl iodides and methyl acrylate was carried out in an X-Cube™ reactor in the presence of supported catalysts. Palladium was immobilised by different methods on silica with covalently grafted ionic liquid moieties. Activity and selectivity of the SILP-Pd (supported ionic liquid phase) catalysts were found to depend greatly on the conditions (such as solvent and additives) of immobilisation. By the proper choice of the methodology used during heterogenisation, a selective catalyst, showing stable performance for hours on stream, was obtained.

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