کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
65373 48389 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cu-modified hydroxy-apatite as catalyst for Glaser–Hay CC homo- coupling reaction of terminal alkynes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Cu-modified hydroxy-apatite as catalyst for Glaser–Hay CC homo- coupling reaction of terminal alkynes
چکیده انگلیسی


• Synthesis and fully characterization of a new Cu modified hydroxyapatite was achieved.
• Cu modified apatite is an efficient catalyst for the Glaser Hay coupling reaction.
• The acetylenic homo-coupling occurs without additive bases and chelating ligands.

The oxidative Glaser–Hay coupling reaction of terminal alkynes is a very important reaction in organic chemistry to achieve the synthesis of diyne compounds. In general the reaction is performed under homogeneous conditions using Cu(I) or Cu(II) salts in the presence of a reagent such as tetramethylethylenediamine (TMEDA), which can bind to copper ions, an organic base and dioxygen. Although this reaction is known for a long time, the mechanism is still under discussion. Pursuing our investigations on the use of apatites as catalysts for organic reactions we highlight in this work how it is possible to catalyze the Glaser–Hay reaction under heterogeneous conditions using a Cu-modified hydroxyapatite (Cu–HAp). With several para-substituted phenyl-acetylenes and alkynols we show that Cu–HAp acts as catalyst for CC coupling reactions leading to diyne derivatives in high yields without using auxiliary chelating molecules and organic bases. These heterogeneous conditions allow an easy recovery of the catalyst and simplify the purification work-up.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis A: Chemical - Volume 393, 1 November 2014, Pages 112–116
نویسندگان
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