کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6551354 | 1421968 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Simultaneous drug identification in urine of sexual assault victims by using liquid chromatography tandem mass spectrometry
ترجمه فارسی عنوان
شناسایی همزمان مواد مخدر در ادرار قربانیان تجاوز جنسی با استفاده از اسپکترومتری جرمی کروماتوگرافی مایع
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کلمات کلیدی
حمله جنسی کروماتوگرافی مایع اسپکترومتری دو طرفه، مواد روانگردان جدید، سوء مصرف مواد، ادرار
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
According to domestic and international epidemiological investigation, the proportion of substance involved sexual assault has the trend of ascent. In the past, laboratory methods that investigated urine sample of the sexual assault victims was to screen with enzyme immunoassay and then confirmed with mass spectrometry. The objective of the study is to simultaneously identify abused drugs in 126 decoded urine samples of sexual assault victims by liquid chromatography tandem mass spectrometry. The instrument was operated in multiple-reaction monitoring with an electro-spray positive ionization mode. Chromatograms were separated with ACE5 C18 column on a gradient of acetonitrile. After liquid-liquid extraction, samples were passed through a 0.22 μm PVDF filter before injection into the system. The limits of quantitation ranged from 0.2 to 10 ng/mL. The precision (CV) results were below 12.9% (intraday) and 15.0% (interday). The intraday accuracy ranged from 84.8 to 121.0%, interday accuracy ranged from 72.0 to 117.3%. We found that 29 (23.0%) were positive for drugs. The most common drug identified is flunitrazepam (11.1%), followed by nimetazepam and ketamine (7.9%), some new psychoactive substances, such as 2C-B, mephedrone, methylone, PMA and PMMA were also identified. We identified abused drugs, benzodiazepines, and new psychoactive substances in urine of sexual assault victims by using liquid chromatography tandem mass spectrometry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International - Volume 282, January 2018, Pages 35-40
Journal: Forensic Science International - Volume 282, January 2018, Pages 35-40
نویسندگان
Hei Hwa Lee, Suen Chi Chen, Jong Feng Lee, Hsin Yu Lin, Bai Hsiun Chen,