کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6551956 | 160421 | 2015 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Methadone-related deaths. A ten year overview
ترجمه فارسی عنوان
مرگ و میر ناشی از متادون. یک نظرسنجی ده ساله
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کلمات کلیدی
متادون، سطوح خون، مرگ، نگهداری،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Twenty-four patients (66.7%) were on methadone maintenance programs for heroin detoxification, while 12 (33.3%) were taking the drug without a medical prescription. The average blood concentration of methadone in patients undergoing a maintenance program was 1.06Â mg/L (0.21-3.37Â mg/L), against 0.79Â mg/L (0.2-3.15Â mg/L) in those taking the non-prescribed drug. Since 111 heroin-related deaths were recorded in our district in the same period, the fact that there appear to be many methadone deaths (about a third of heroin-related deaths) cannot be overlooked. The aim of this work is to understand the possible reasons for such a large number of methadone-related deaths. On this subject, we have noticed that risks associated with methadone intake are often underestimated by clinicians prescribing the drug: sometimes methadone is prescribed without taking into account patient's tolerance to opiates, and a large number of subjects enrolled in methadone maintenance programs in Italy, have also been given take-home doses, thus increasing the risk of abuse and diversion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International - Volume 257, December 2015, Pages 172-176
Journal: Forensic Science International - Volume 257, December 2015, Pages 172-176
نویسندگان
Claudia Vignali, Cristiana Stramesi, Luca Morini, Fulvia Pozzi, Angelo Groppi,