Palladium-catalyzed arylation of aryl sulfonamides with cyclohexanones

• A Pd-catalyzed intermolecular aerobic dehydrogenative aromatizations of cyclohexanones with aryl sulfonamides is described.
• Cyclohexanones acted as aryl sources via dehydrogenation and tautomerization.
• Various N-aryl sulfonamides were selectively obtained in good yield using molecular oxygen as oxidant.
• Functional groups were well tolerated under the optimized reaction conditions.

Pd-catalyzed intermolecular aerobic dehydrogenative aromatizations have been developed for the arylation of aryl sulfonamides with cyclohexanones. Various N-aryl sulfonamides were selectively obtained in good yields using molecular oxygen as oxidant. The reaction tolerated a wide range of functionalities.

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