کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
65653 | 48399 | 2013 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Enantioselective hydrogenation of β-dehydroamino acids on a cinchonidine-modified palladium catalyst Enantioselective hydrogenation of β-dehydroamino acids on a cinchonidine-modified palladium catalyst](/preview/png/65653.png)
• Heterogeneous enantioselective hydrogenation of β-dehydroamino acids was achieved.
• The enantioselectivity approached 46% for alky substituted β-dehydroamino acids.
• The β-dehydroamino acids interacted efficiently with the chiral modifier.
• This result offered a new approach to synthesize optical β-amino acids.
Enantioselective hydrogenation of (Z)-β-dehydroamino acids on a cinchonidine-modified Pd/Al2O3 catalyst was explored. Comparative studies by using (Z)-β-dehydroamino acids and esters identified that the carboxylic group in dehydroamino acids was essentially important to get enantioselectivities (33% for aryl substituted and 46% for alkyl substituted β-dehydroamino acids). This result extended the range of enantioselective hydrogenation of α,β-unsaturated carboxylic acids on chirally modified Pd catalysts and offered a new approach to synthesize optically active β-amino acids.
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Journal: Journal of Molecular Catalysis A: Chemical - Volume 379, 15 November 2013, Pages 117–121