کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
65723 48401 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and application of new iminopyridine ligands in the enantioselective palladium-catalyzed allylic alkylation
ترجمه فارسی عنوان
سنتز و کاربرد لیگاندین های جدید ایمینوپیریدین در آلکیل کردن آللیه آلتیلیت آلانیته
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
چکیده انگلیسی


• New chiral iminopyridines were obtained from pyridyl and quinolinyl aldehydes.
• New chiral iminopyridines were obtained from a variety of chiral or achiral amines.
• New ligands were assessed in the enantioselective Pd-catalyzed allylic substitution.
• 1,3-Diphenylprop-2-enylmalonate was obtained with enantioselectivities up to 62% ee.

A variety of iminopyridines were obtained by condensation of chiral amines with pyridine-2-carboxaldehyde and quinoline-8-carbaldehyde, or of aminoalkylpyridine derivatives with chiral ketones. These ligands were assessed in the enantioselective palladium catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate affording the product dimethyl 1,3-diphenylprop-2-enylmalonate in good yields and moderate enantioselectivities (up to 62% ee). Catalytic activity and enantioselectivity were found to be highly dependent upon the steric properties of the ligands. The best enantioselectivity (62% ee) was obtained by an iminopyridine based on a camphane skeleton.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis A: Chemical - Volume 385, April 2014, Pages 73–77
نویسندگان
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