Control of particle size, at micrometric and nanometric range, using supercritical antisolvent precipitation from solvent mixtures: Application to PVP

Using pure DMSO, NMP or EtOH, it is possible to produce spherical PVP microparticles (with a mean diameter lower than 3.8 μm); whereas, using mixtures of these solvents with acetone, PVP nanoparticles (with a mean diameter down to 0.11 μm) were precipitated.