H5PW10V2O40/Pip-SBA-15: A novel reusable organic–inorganic hybrid material as potent Lewis acid catalyst for one-pot solvent-free synthesis of 3,4-dihydropyrimidinones

A simple and environmentally friendly one-pot three components methodology has been commented for the Biginelli condensation of different substituted aldehydes with ethyl acetoacetate and urea to afford the corresponding 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions. H5PW10V2O40/Pip-SBA-15 was used as a non-toxic, inexpensive, and easily available organic–inorganic hybrid material as the catalyst. Utilization of easy reaction condition and simple work-up makes this methodology as an interesting option for the economic synthesis of dihydropyrimidinones.

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► Modification of SBA-15 with piperazine to avoid leaching of the heteropolyacid.
► An environmentally friendly protocol to afford dihydropyrimidinones.
► SBA/Pip/H5PW10V2O40 as a new organic–inorganic hybrid material.
► Piperazine behaved as the best among various organic linkers.