کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
660819 1458141 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Water and solute active transport through human epidermis: Contribution of electromigration
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی جریان سیال و فرایندهای انتقال
پیش نمایش صفحه اول مقاله
Water and solute active transport through human epidermis: Contribution of electromigration
چکیده انگلیسی
A triphasic, coarse-grained model of mass transport through the human epidermis is developed, consisting of free extracellular water, live cells (keratinocytes), and inert extracellular matrix. The model accounts for the superposition of active transport of Na+, K+ and Cl− ions across the membrane of keratinocytes, and electromigration driven by an externally imposed electrostatic potential difference. Local cell volume is regulated by the transmembrane fluxes of water and ions according to a time-delay scheme which aims to keep the volume between certain thresholds. Numerical simulations reveal that either weak hyposmotic shocks or negative potential gradients smaller than one millivolt/micrometer across the epidermis can generate travelling waves in extracellular ion concentration. By monitoring the transmembrane (Na+−K+ −ATPase) pump flux, we have found that maintaining a higher transepidermal potential gradient requires faster active transport through the cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Heat and Mass Transfer - Volume 51, Issues 23–24, November 2008, Pages 5623-5632
نویسندگان
, ,