کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
660819 | 1458141 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Water and solute active transport through human epidermis: Contribution of electromigration
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
جریان سیال و فرایندهای انتقال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A triphasic, coarse-grained model of mass transport through the human epidermis is developed, consisting of free extracellular water, live cells (keratinocytes), and inert extracellular matrix. The model accounts for the superposition of active transport of Na+, K+ and Clâ ions across the membrane of keratinocytes, and electromigration driven by an externally imposed electrostatic potential difference. Local cell volume is regulated by the transmembrane fluxes of water and ions according to a time-delay scheme which aims to keep the volume between certain thresholds. Numerical simulations reveal that either weak hyposmotic shocks or negative potential gradients smaller than one millivolt/micrometer across the epidermis can generate travelling waves in extracellular ion concentration. By monitoring the transmembrane (Na+âK+ âATPase) pump flux, we have found that maintaining a higher transepidermal potential gradient requires faster active transport through the cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Heat and Mass Transfer - Volume 51, Issues 23â24, November 2008, Pages 5623-5632
Journal: International Journal of Heat and Mass Transfer - Volume 51, Issues 23â24, November 2008, Pages 5623-5632
نویسندگان
Cibele V. Falkenberg, John G. Georgiadis,