کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
660820 1458141 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Unsteady, three-dimensional fluid mechanic analysis of blood flow in plaque-narrowed and plaque-freed arteries
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی جریان سیال و فرایندهای انتقال
پیش نمایش صفحه اول مقاله
Unsteady, three-dimensional fluid mechanic analysis of blood flow in plaque-narrowed and plaque-freed arteries
چکیده انگلیسی

Fluid mechanic analysis is used to create and implement a metric to quantify the effectiveness of plaque removal (i.e., debulking) modalities in small arteries. The quantification is based on a three-dimensional, unsteady model of blood flow in complex tubular geometries which characterizes plaque-narrowed arteries. Blood flow unsteadiness is due to the heart-imposed temporal variations which occur during the cardiac cycle. The arterial geometries used for the analysis were determined by the reconstruction of ultrasonic images which were captured before and after debulking. Numerical simulation was used to implement the fluid mechanic model, and separate consideration is given to Newtonian and non-Newtonian constitutive equations. The results of the analysis indicates that the removal of the plaque led to an increase in the rate of blood flow of approximately 2.5, both during the systole and diastole portions of the cardiac cycle. This increase corresponds to the application of the same time-varying, end-to-end pressure difference across the artery segments. The shear stress on the artery wall, a major determinant of the buildup of plaque, is found to be higher for a debulked artery than for a plaque-narrowed artery. This outcome is favorable in that the higher the wall shear, the lower the rate of plaque formation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Heat and Mass Transfer - Volume 51, Issues 23–24, November 2008, Pages 5633–5641
نویسندگان
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