Molybdate sulfuric acid as a reusable solid catalyst in the synthesis of 2,3,4,5-tetrasubstituted pyrroles via a new one-pot [2+2+1] strategy

Molybdate sulfuric acid (MSA) has been found as an efficient and reusable solid acid catalyst for the synthesis of new 2,3,4,5-tetrasubstituted pyrroles via a novel [2+2+1] strategy. Thus, one-pot three-component reaction of benzoin derivatives, 1,3-dicarbonyls, and ammonium acetate afforded the desired products in high yield under solvent-free conditions.

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► MSA catalyzes efficiently the one-pot [2+2+1] strategy for the synthesis of substituted pyrroles.
► The yield of MSA-catalyzed reaction of 1,3-dicarbonyls, NH4OAc, and benzoins is high.
► This heterogeneous solid acid catalyst is recyclable.
► Electron-deficient benzoins reacted much faster than the others in the presence of MSA.