Synthesis of diarylpyrimidinones (DAPMs) using large pore zeolites

A series of diarylpyrymidin-2(1H)-one (DAPM) belongs to one of the important class of therapeutic and pharmacological active hetrocycles, were synthesized through the multicomponent reactions (MCRs) of aldehydes, ketone and urea, followed by the heterogeneous catalysis. The synthetic utility of this method is well demonstrated by avoiding expensive reagent TMSCl, using large pore zeolites (H-MOR, HY and H-BEA) as potential solid acid catalyst. Key role of textural properties such as surface acidity, hydrophobicity and porosity on catalytic activity of the zeolites on the synthesis of DAPMs has also been described.

One pot synthesis of diarylpyrymidin-2(1H)-ones (DAPMs) has been carried out using zeolite as an efficient solid acid catalyst. This heterogeneous green protocol offers easy access to DAPMs in excellent yield (70–88%) compared to other reported methods. Further, the catalyst has been recycled up to five run without any significant loss of its activity.Figure optionsDownload high-quality image (132 K)Download as PowerPoint slideHighlights
► MCRs of biological active DAPM over various large pore zeolites have been studied.
► Focus on elimination of an expensive reagent TMSCl, using large pore zeolites.
► Discussion on plausible mechanism of DAPM synthesis over zeolite.