Unique versatility of Amberlyst 15. An acid and solvent-free paradigm towards synthesis of bis(heterocyclyl)methane derivatives

Bis(heterocyclyl)methanes, key intermediates for a variety of chemical, biochemical and material science relevant targets, have been obtained in a synthetically useful manner using Amberlyst 15 ion-exchange resin. This method promises versatility, cost-effectiveness, and efficiency.

Bis(heterocyclyl)methanes, key intermediates for a variety of chemical, biochemical and material science relevant targets, have been obtained in a synthetically useful manner using Amberlyst 15 ion-exchange resin. This method promises versatility, cost-effectiveness, and efficiency.Figure optionsDownload high-quality image (104 K)Download as PowerPoint slideHighlights
► Bis(heterocyclyl)methanes have been synthesized in good yields using Amberlyst 15 as catalyst.
► This catalytic approach provides synthetic flexibility as various heterocycles have been prepared.
► It employs recyclable catalyst of industrial and environmental significance.
► The reaction is run without any solvent medium.