Modelling of the pH dynamic and its effect over the Isopropanol-Butanol-Ethanol fermentation by Clostridium acetobutylicum pIPA3-Cm2

The proposed model attained a correlation index R2 = 0.9931 and a p-value <0.001 versus experimental data reported by Lee at al. (2012), predicting a total of 20.1617 kg m−3 of IBEs with a yield of 0.3341 kgIBE kgSg−1 after 42 h of batch fermentation. Additionally, both the proposed parameters for critical and optimal pH (pHc = 3.4977; pHop = 6.5) and simulation results based on the equation proposed for the modelling of the pH dynamic were consistent with experimental reports for both ABE and IBE fermentation systems under a wide array of operational conditions.