کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6661534 | 1426551 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Formation of polypyrrole with dexamethasone as a dopant: Its cation and anion exchange properties
ترجمه فارسی عنوان
تشکیل پلی پریورل با دگزامتازون به عنوان یک ماده افزودنی: خواص کاتدی و آنیونی آن
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
چکیده انگلیسی
There is considerable interest in dexamethasone, a synthetic glucocorticosteroid drug, and a number of reports detailing the controlled release of dexamethasone from polypyrrole have been published. However, polypyrrole-doped with dexamethasone is poorly characterised. In this study, polypyrrole doped with dexamethasone was formed at relatively low applied potentials of 0.70â¯V or 0.80â¯V vs SCE by carrying out the electropolymerisation on an initial pre-layer of polypyrrole. These polymers displayed electroactive behaviour with a dexamethasone doping level of 0.30â¯Â±â¯0.03 and using impedance measurements the charge-transfer resistance was computed as 400â¯Î©. Mixed ion transport was observed. In addition to the release of dexamethasone, hydrated sodium cations were incorporated to maintain charge neutrality on reduction of the polymer. Approximately 200â¯Î¼gâ¯cmâ2 of dexamethasone was released following 60â¯min on reduction of the polymer at â0.90â¯V vs SCE. It was possible to re-use the polymer to release the drug by repeated oxidation and reduction steps, where dexamethasone was incorporated during oxidation and released on reduction. During these events, sodium was accumulated within the polymer matrix and this high salt content accompanied with swelling and de-swelling events gave rise to the development of cracks in the polymer matrix.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electroanalytical Chemistry - Volume 824, 1 September 2018, Pages 188-194
Journal: Journal of Electroanalytical Chemistry - Volume 824, 1 September 2018, Pages 188-194
نویسندگان
Eimear M. Ryan, Carmel B. Breslin,