کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6661790 | 1426557 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selective and sensitive voltammetric determination of folic acid using graphite/restricted access molecularly imprinted poly(methacrylic acid)/SiO2 composite
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The present study demonstrates the development of a voltammetric sensor based on graphite/restricted access molecularly imprinted poly(methacrylic acid)/SiO2 composite for folic acid determination in pharmaceutical formulation. The insertion of hybrid molecularly imprinted polymer with restricted access (RAM-MIP) into the graphite paste provided enhance in the cathodic peak current for FA. As the electric conductivity of RAM-MIP is very poor, the optimum content was found to be very low (3%, w/w) in the composite. Under optimized conditions (0.1â¯molâ¯Lâ1 Britton-Robinson buffer and pHâ¯4.5) using square wave voltammetry (frequency of 150â¯Hz, pulse amplitude of 90â¯mV and potential increment of 7â¯mV) a limit of detection of 0.72â¯Î¼gâ¯Lâ1 (1.63â¯nmolâ¯Lâ1) and a linear range from 5.0 to 100.0â¯Î¼gâ¯Lâ1 (0.01 to 0.23â¯Î¼molâ¯Lâ1) were obtained. The method precision was assessed in terms of inter-day (nâ¯=â¯6) and intra-day precision (two consecutive days), whose relative standard deviations (RSD%) ranged from 3.56 to 5.01%. The developed method was applied for FA determination in pharmaceutical samples whose accuracy was attested by means of addition and recovery assays (97.7-105.0%) as well as by high performance liquid chromatography (HPLC) as a reference technique, thus indicating that RAM-MIP sensor might be successfully applied for quality control in the real samples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electroanalytical Chemistry - Volume 818, 1 June 2018, Pages 223-230
Journal: Journal of Electroanalytical Chemistry - Volume 818, 1 June 2018, Pages 223-230
نویسندگان
Michele Kuceki, Fernanda Midori de Oliveira, Mariana Gava Segatelli, Malena Karla Lombello Coelho, Arnaldo César Pereira, Luana Rianne da Rocha, Jhessica de Cássia Mendonça, César Ricardo Teixeira Tarley,