Electrochemical behavior and voltammetric determination of pyrazinamide using a poly-histidine modified electrode

► Development of low cost voltammetric detector for determination of pyrazinamide using a screen printed modified electrodes. ► Poly-histidine films preparation and its application for electrocatalytic reduction of pyrazinamide. ► Cyclic voltammetry and electrochemical impedance spectroscopy applied for elucidation of pyrazinamide reduction process. ► Low detection limit, good sensitivity and excellent stability of the screen printed carbon electrode. ► Determination of pyrazinamide in simulated human urine without any pretreatment of the sample.