Extraction of phytochemicals from saffron by supercritical carbon dioxide with water and methanol as entrainer

- Optimum conditions of phytochemicals of saffron using SC-CO2 method with entrainer were revealed.
- Picrocrocin, HTCC, safranal, α-crocin, and deglycosylated crocin were extracted successfully.
- Yield by SC-CO2 method were higher than that by H2O and MeOH extraction.
- SC-CO2 method with entrainer was suitable for extraction of hydrophilic and hydrophobic component.