Response surface optimization of Smyrnium cordifolium Boiss (SCB) oil extraction via supercritical carbon dioxide

- The essential oil of aerial parts of Smyrnium cordifolium Boiss (SCB) was extracted by supercritical CO2.
- Design of experiments was carried out with response surface methodology.
- Operating variables are pressure, temperature, CO2 flow rate and extraction dynamic time.
- Optimizing process was done to achieve maximum yield extraction.