Regioselective ring opening of epoxides with amines using monodispersed silica nanoparticles in water

Monodispersed silica nanoparticles were synthesized and used as catalyst for the regioselective synthesis of β-amino alcohols in water via nucleophilic ring opening of epoxides with amines under ambient conditions in shorter reaction times. The use of water as ‘green’ solvent allows easy recycling of the catalyst.

Monodispersed silica nanoparticles were synthesized and used as catalyst for the regioselective synthesis of β-amino alcohols in water via nucleophilic ring opening of epoxides with amines under ambient conditions in shorter reaction times. The use of water as ‘green’ solvent allows easy recycling of the catalyst with consistent activity.Figure optionsDownload as PowerPoint slide