Rare-earth metal triflates catalyzed three-component coupling of aldehydes, ketones or ketoesters and benzyl carbamate: An efficient one-pot stereoselective synthesis of Cbz-protected β-amino carbonyl compounds

Sc(OTf)3 and Yb(OTf)3 have been found to be efficient catalysts for one-pot three-component coupling of aldehydes, ketones or ketoesters and benzyl carbamate in acetonitrile at room temperature to furnish the corresponding Cbz-protected β-amino ketones in impressive yields and good diastereoselectivity.

One-pot three-component coupling of aldehydes, ketones or ketoesters and benzyl carbamate in acetonitrile in presence of Sc(OTf)3 or Yb(OTf)3 at room temperature produced the corresponding Cbz-protected β-amino ketones in high yields and good diastereoselectivity. Figure optionsDownload as PowerPoint slide