کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
67660 | 48490 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: TMSCl–NaI-mediated reaction of aryl azides with cyclic enol ethers: An efficient one-pot synthesis of 1,2,3,4-tetrahydroquinolines TMSCl–NaI-mediated reaction of aryl azides with cyclic enol ethers: An efficient one-pot synthesis of 1,2,3,4-tetrahydroquinolines](/preview/png/67660.png)
The tetrahydroquinoline moiety is an important structural component of a number of natural products. The reaction of aryl azides with 2,3-dihydro-2H-furan and 3,4-dihydro-2H-pyran in the presence of chlorotrimethylsilane-sodium iodide (TMSCl–NaI) affords the corresponding 1,2,3,4-tetrahydroquinoline derivatives in an efficient manner and most of these compounds exhibited cis selectivity. The aza-Diels–Alder reaction may proceed through in situ generation of aryl amines followed by the reaction between 2-azadiene and another equivalent of cyclic enol resulting in the formation of 1,2,3,4-tetrahydroquinolines.
The tetrahydroquinoline moiety is an important structural component of a number of natural products. The reaction of aryl azides with 2,3-dihydro-2H-furan and 3,4-dihydro-2H-pyran in presence of TMSCl–NaI affords the corresponding 1,2,3,4-tetrahydroquinoline derivatives in an efficient manner and most of these compounds exhibited cis selectivity.Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Catalysis A: Chemical - Volume 274, Issues 1–2, 3 September 2007, Pages 133–136