کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
67705 | 48492 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: (R,R)-DPEN-modified Ru/γ-Al2O3—An efficient heterogeneous catalyst for enantioselective hydrogenation of acetophenone (R,R)-DPEN-modified Ru/γ-Al2O3—An efficient heterogeneous catalyst for enantioselective hydrogenation of acetophenone](/preview/png/67705.png)
An efficient enantioselective catalyst of 5 wt.% Ru/γ-Al2O3 modified with R,R-1,2-diphenylethylene-diamine ((R,R)-DPEN) for the hydrogenation of a non-activated aromatic ketone of acetophenone has been investigated, a relatively high enantiomeric excess (ee) of 60.5% was obtained at both the conversion and selectivity larger than 99%, it was about three times higher than the ee values reported up to now for acetophenone hydrogenation with the supported transition metal catalysts modified by chiral reagents. The influences of some reaction parameters such as phosphine ligand, substrate/catalyst/modifier molar ratios, base, solvent, pressure and reaction temperature have been discussed. The chiral modifier of (R,R)-DPEN was very important in controlling the enantioselectivity through adsorption competing with other substrates on the surface of active metal species. The phosphine ligand and base were also important and indispensable in the present reaction.
A higher ee value of 60.5% has been obtained for enantioselective hydrogenation of acetophenone with a 5 wt.% Ru/γ-Al2O3 catalyst modified by R,R-1,2-diphenylethylene-diamine and phosphine ligand. Figure optionsDownload as PowerPoint slide
Journal: Journal of Molecular Catalysis A: Chemical - Volume 278, Issues 1–2, 14 December 2007, Pages 6–11