Previous estradiol treatment in ovariectomized mice provides lasting enhancement of memory and brain estrogen receptor activity

- Ovariectomized mice received continuous estradiol or vehicle treatment.
- After 40 days all treatments were terminated.
- One month after treatments ended memory and estrogen receptor activity were assayed.
- Previous estradiol enhanced hippocampus-dependent memory.
- Previous estradiol increased estrogen receptor activation in hippocampus and cortex.